Plant i - AAA protease controls the turnover of the essential mitochondrial protein import component

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The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component.

Mitochondria are multifunctional organelles that play a central role in energy metabolism. Owing to the life-essential functions of these organelles, mitochondrial content, quality and dynamics are tightly controlled. Across the species, highly conserved ATP-dependent proteases prevent malfunction of mitochondria through versatile activities. This study focuses on a molecular function of the pl...

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Recent studies have revealed a role for the ubiquitin/proteasome system in the regulation and turnover of outer mitochondrial membrane (OMM)-associated proteins. Although several molecular components required for this process have been identified, the mechanism of proteasome-dependent degradation of OMM-associated proteins is currently unclear. We show that an AAA-ATPase, p97, is required for t...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2017

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.200733